Atm förmedlar specifikt reparation av dubbelsträngspauser

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In view of prior preliminary evidence suggesting defective mitochondrial function in cells of patients with Ataxia Pharmacological ATM inhibition by KU55933 in cisplatin-treated mice did not ameliorate, but instead exacerbated cisplatin-induced DNA damage and tubular injury, thereby increasing mortality. KU-55933 ATM Inhibitor 10-1518-5mg Cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated), a serine/threonine pr Here we tested if chemically inhibiting ATM in the absence of PARP-1 or inhibiting PARP-1 in the absence of ATM increased toxicity to each inhibitor in mammalian cells. We found that PARP-1 defective mouse embryonic fibroblast (MEF) cells (A11) were more sensitive to the ATM inhibitor KU55933 than A19 wild-type cells ( Figure 1A). The roles of ATM in stimulating glucose uptake, glycolysis, motility, and proliferation of cancer cells were demonstrated by knocking-down ATM in these cells. KU-55933 treatment also inhibits tumor growth and metastasis in vivo in mouse mammary tumors through inhibition of GLUT1 translocation and vimentin expression. Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin Mahvash Zakikhani1,2, Miguel Bazile2, Sina Hashemi2, Shiva ATM deficiency increases TMZ sensitivity, which suggests that ATM inhibitors may be effective TMZ sensitizing agents. In this study, the TMZ sensitizing effects of 2 ATM specific inhibitors were studied in established and xenograft-derived glioblastoma (GBM) lines that are inherently sensitive to TMZ and derivative TMZ-resistant lines.

Ku55933 atm inhibitor

ab120637 KU-55933, competitive ATM kinase inhibitor （CAS番号: 587871-26-9）分子量: 395.49 化学式: C21H17NO3S2 Potent, 選択的, competitive ATM kinase 阻害剤アブカムの高純度な生理活性物質（アゴニスト・アンタゴニスト・アクティベーター・阻害剤） 2016-09-09 · To evaluate whether ATM inhibition increases the cytotoxicity of PARP inhibitors, we treated both triple-negative breast cancer cell lines (CAL-51, MDA-MB-231 and MDA-MB-468) and non-triple-negative breast cancer cell lines (MCF-7, T-47D and SK-BR-3) with increasing concentrations of Olaparib (0–10 μM) alone or in combination with 10 μM ATM inhibitor KU55933. ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM). - Find MSDS or SDS, a COA, data sheets and more information. Sometimes, whether you’re on a trip or you need cash on the weekend, it’s difficult to find an ATM. You’ll see this is especially challenging if you’ve just moved to a new area. These guidelines will help you regarding locating an ATM near Advertisement By: Christopher Lampton ATMs are fast and convenient, but they can also cost you money. Let's consider some alternatives to hitting the local ATM every other day.

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KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR. For ATM inhibition experiment, ATM inhibitor KU55933 (Selleck, Houston, USA) was added to culture medium 2 h before addition of 25 μM RSV. Techniques: Western Blot, Expressing, Immunofluorescence, Staining, Laser-Scanning Microscopy, Incubation, Activation Assay, Flow Cytometry, Cytometry (A, B, and C) U2OS cells were pretreated with ATM inhibitor caffeine (A), wortmannin (B), or KU55933 (C) and then subjected to IR. Cells were harvested at the indicated time points .

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Our study shows that a specific ATM inhibitor, KU-55933, blocks the phosphorylation of Akt induced by insulin and insulin-like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU-55933 inhibits cancer cell proliferation by inducing G 1 cell cycle arrest. KU55933 is a selective and reversible inhibitor of the activity of ATM and thus can be used to transiently inhibit ATM kinase activity in cells (29). Previous work suggested that ATM has temporally distinct functions in cells exposed to IR. Here we demonstrate that the treatment of intracellular tachyzoites with the PI3K inhibitor caffeine or ATM kinase-inhibitor KU-55933 affects parasite replication rate in a dose-dependent manner. KU-55933 affects intracellular tachyzoite growth and induces G1-phase arrest.

The addition of ATM inhibitor KU55933 to GRN163L/etoposide combination treatment increased cytotoxicity further, as observed in MCF-7 breast cancer cells. A previous model proposed that telomerase acts upstream from ATM activation and that telomerase inhibition prevents ATM activation through the structural regulation of chromatin . Find and order inhibitors and products like this ATM Kinase Inhibitor, KU-55933 on www.antibodies-online.com. Order product ABIN412287. ab120637 KU-55933, competitive ATM kinase inhibitor （CAS番号: 587871-26-9）分子量: 395.49 化学式: C21H17NO3S2 Potent, 選択的, competitive ATM kinase 阻害剤アブカムの高純度な生理活性物質（アゴニスト・アンタゴニスト・アクティベーター・阻害剤） 2016-09-09 · To evaluate whether ATM inhibition increases the cytotoxicity of PARP inhibitors, we treated both triple-negative breast cancer cell lines (CAL-51, MDA-MB-231 and MDA-MB-468) and non-triple-negative breast cancer cell lines (MCF-7, T-47D and SK-BR-3) with increasing concentrations of Olaparib (0–10 μM) alone or in combination with 10 μM ATM inhibitor KU55933. ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem ATM Kinase Inhibitor, CAS 587871-26-9, is a cell-permeable, potent, ATP-competitive inhibitor of ATM Kinase (IC₅₀ = 13 nM; Ki = 2.2 nM).
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Atm förmedlar specifikt reparation av dubbelsträngspauser

Potent and selective ATM kinase inhibitor. Cited in 77 publications. KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

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KU‑55933 (ATM Kinase Inhibitor)可抑制 autophagy‑initiating kinase ULK1 的激活从而导致自噬的显著减少。. KU-55933 is a specific ATM inhibitor with IC50 value of 13nM and Ki value of 2.2nM View and buy high purity KU 55933 from Tocris Bioscience. Potent and selective ATM kinase inhibitor. Cited in 77 publications. KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.